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What to Expect: NFL Schedule Release for Colts on Wednesday

May 13, 2025 by Stampede Blue

NFL: NOV 10 Bills at Colts
Photo by Jeffrey Brown/Icon Sportswire via Getty Images

Colts fans should officially know when their favorite squad is playing each of its 2025 opponents around mid-week.

The NFL has announced that this upcoming 2025 regular season schedule will be released this Wednesday, May 14th at 8 PM EST.

Colts fans can watch the schedule release NFL Network and stream it on NFL+, as the league will host its annual special show.

Various NFL broadcast partners such as NBC, ESPN, and CBS will announce select games leading up to the NFL’s schedule full release.

The Colts already know their 2025 opponents, it’s just a matter of the date and time of when they’ll play each of them—including having one international game in Berlin, Germany:

HOME

  • Houston Texans
  • Jacksonville Jaguars
  • Tennessee Titans
  • Atlanta Falcons
  • Arizona Cardinals
  • Denver Broncos
  • Las Vegas Raiders
  • Miami Dolphins
  • San Francisco 49ers

AWAY

  • Houston Texans
  • Jacksonville Jaguars
  • Tennessee Titans
  • Kansas City Chiefs
  • Los Angeles Chargers
  • Los Angeles Rams
  • Pittsburgh Steelers
  • Seattle Seahawks

According to Sharp Football Analysis, the Colts have the 12th easiest strength of schedule, which is the 3rd most favorable in the AFC South, but significantly better than the reigning AFC South champion Houston Texans—who have the 8th hardest SOS next year.

At any rate, we should know soon enough when and what time the Colts will be facing their full slate of opponents for this upcoming season.

Personally, I’m really looking forward to the 49ers coming into town because between the Colts’ Shane Steichen and 49ers’ Kyle Shanahan, that should be some fun offensive play-calling and designs between two gifted young offensive minds—with what could be a high scoring affair among the pair’s squads.

It’s also nice to see a opponent we haven’t seen in a a while at home, and the Colts haven’t played the 49ers since 2021, let alone hosted them which was back in October of 2017.

Filed Under: Colts

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